The HVAC and refrigeration industry is experiencing significant growth, driven by the increasing demand for sophisticated, energy-efficient, and smart HVAC systems (heating, ventilation, and air conditioning). R152A refrigerant is recognized as a highly effective and low-GWP (Global Warming Potential) refrigerant in residential refrigeration, commercial refrigeration, industrial refrigeration, automotive HVAC, and general air conditioning systems.
This guide provides information about R152A refrigerant, including its definition, applications, characteristics, and more.
What is R152a Refrigerant?

R152A refrigerant is a pure azeotropic HFC (hydrofluorocarbon) refrigerant used in medium temperature refrigerant applications with superior cooling performance and high-energy-efficiency requirements. It is known by its lower GWP of 138 (IPCC AR5) or 124 (IPCC AR4), and zero Ozone Depletion Potential (ODP).
Because of its thermophysical characteristics and thermodynamic properties, R152A refrigerant is considered a top choice (as an R134a alternative) for HVAC, refrigeration, and high-temperature cooling systems.
R152a (DFE or difluoroethane) is classified as an A2 (mildly to slightly flammable) refrigerant. R152A is a non-toxic refrigerant (class A2). R-152a refrigerant is chemically known as 1,1-Difluoroethane (C2H4F2), R152a (difluoroethane), Difluoroethane, R152a Refrigerant Gas, hydrofluorocarbon (HFC) refrigerant, and refrigerant R152a Gas.
R152A Refrigerant Properties
Knowing about the properties of R152a helps you evaluate its performance, efficiency, and suitability as a lower-GWP alternative to R134a. The table below summarizes the key properties of R152a refrigerant.
| Property | R152A Refrigerant |
| Chemical Name | 1,1-Difluoroethane |
| Refrigerant Number | R152a |
| Chemical Formula | C₂H₄F₂ |
| Molecular Weight | 66.05 g/mol |
| ASHRAE Safety Classification | A2 (Low Toxicity, Flammable) |
| Ozone Depletion Potential (ODP) | 0 |
| Global Warming Potential (GWP, AR4) | 124 |
| Global Warming Potential (GWP, IPCC) | 138 ( AR5) / 124 ( AR4) |
| Boiling Point (1 atm) | -24.7°C (-12.5°F; 248.5 K ) |
| Critical Temperature | 113.3°C (235.9°F) |
| Critical Pressure | 4.52 MPa |
| Critical Density | 368 kg/m³ |
| Liquid Density (25°C) | 911 kg/m³ |
| Vapor Density (25°C) | 2.8 kg/m³ |
| Vapor Pressure | 536 kPa |
| Latent Heat of Vaporization (-25°C) | 286 kJ/kg |
| Flammability | Flammable |
| Lubricant Compatibility | POE Oil |
| Temperature Glide | 0°C (Pure Refrigerant) |
R152A Refrigerant Pressure Temperature Chart
| R-152A(PSIG) | ℉ | ℃ |
| -7.8 | -40 | -40 |
| -6.8 | -35 | -37.2 |
| -5.6 | -30 | -34.4 |
| -4.3 | -25 | -31.7 |
| -2.9 | -20 | -28.9 |
| -1.3 | -15 | -26.1 |
| 0.5 | -10 | -23.3 |
| 2.4 | -5 | -20.6 |
| 4.5 | 0 | -17.8 |
| 6.9 | 5 | -15 |
| 9.4 | 10 | -12.2 |
| 12.2 | 15 | -9.4 |
| 15.3 | 20 | -6.7 |
| 18.6 | 25 | -3.9 |
| 22.1 | 30 | -1.1 |
| 26 | 35 | 1.7 |
| 30.2 | 40 | 4.4 |
| 34.6 | 45 | 7.2 |
| 39.4 | 50 | 10 |
| 44.6 | 55 | 12.8 |
| 50.1 | 60 | 15.6 |
| 56.1 | 65 | 18.3 |
| 62.4 | 70 | 21.1 |
| 69.1 | 75 | 23.9 |
| 76.3 | 80 | 26.7 |
| 83.9 | 85 | 29.4 |
| 92 | 90 | 32.2 |
| 100.6 | 95 | 35 |
| 109.7 | 100 | 37.8 |
| 119.3 | 105 | 40.6 |
| 129.5 | 110 | 43.3 |
| 140.2 | 115 | 46.1 |
| 151.6 | 120 | 48.9 |
| 163.5 | 125 | 51.7 |
| 176.1 | 130 | 54.4 |
| 189.3 | 135 | 57.2 |
| 203.2 | 140 | 60 |
| 217.8 | 145 | 62.8 |
| 233.1 | 150 | 65.6 |
Key Applications of R152A Refrigerant
R152a refrigerant finds extensive applications across several industries, including:
Commercial refrigeration

Refrigerant R152a is essential for industries with cooling technology needs, such as the food industry, hospitality, pharmaceutical, and health care. Refrigerant R152a has superior energy efficiency and efficient cooling, making it preferred for businesses that rely on commercial refrigeration systems to maintain food quality and display perishable goods such as meat, dairy, and beverages. Key applications include medium-temperature commercial refrigeration, cold storage, cold chain, walk-in coolers, freezing equipment, refrigeration racks, and centralized rack systems.
Residential refrigeration

The demand for energy-efficient appliances and air conditioning units is rising, R152a refrigerant is increasingly used in residential refrigeration systems, such as domestic fridges, freezers, household refrigerators, household cooling, air conditioning units, and HVAC systems, due to its superior thermodynamic properties and low-pressure operation, refrigerant R152a can ensure up to 13.4% higher coefficient of performance (COP), and 10.6% lower electrical power consumption for domestic cooling systems.
Because of R152a refrigerant’s A2 safety rating, it is commonly used in secondary loop systems, specific industries, or mixed refrigerants. It is rarely directly used as the main refrigerant for large-scale commercial cold storage or traditional household refrigerators, and is more commonly used as an original material for mixed refrigerants
Industrial refrigeration

Refrigerant R152A are popular for large-scale industrial refrigeration systems such as raw materials manufacturing plants, chemical manufacturing, ammonia refrigeration systems, food refrigeration, warehousing and distribution, due to its large cooling capacity, high performance, and low flammability risk when properly handled, refrigerant R152A can meet efficiently the cooling and freezing needs of food supply chain, from production to consumption, while it can preserve the freshness of various food and prevents bacterial growth and spoilage. Common applications include industrial refrigeration solutions, industrial chiller plants, and industrial cooling equipment.
Automotive refrigeration

The automotive demand is growing, refrigerant R152A is a low-GWP refrigerant that align with the strict regulations of global warming, and greenhouse gas emissions, automotives industry utilizes R152a refrigerant to provide high cooling capacity and superior efficiency to automotive refrigeration applications such as, mobile air conditioning (MAC), cars air conditioning, vehicles air conditioning, vehicles refrigerant, vehicle heat pump system, electric vehicle (EV) cooling, transport refrigeration, temperature-controlled transport, trucks cooling units and cooling containers.
Other applications
Refrigerant R152A is increasingly used in medium-temperature refrigeration applications such as:
Refrigerant blends
Specialty gas blends
Portable/Plug-in cooling
Aerosol propellants
Foam-blowing agent
Heat pump systems
Advantages of Refrigerant R152a refrigerant
Refrigerant R-152a is recognized for its favorable thermodynamic characteristics, compatibility, and performance, making it suitable for specific refrigeration and air conditioning systems.
Compatibility
Refrigerant R152a (1,1-Difluoroethane) is generally compatible with the majority of materials such as POE (polyolester) synthetic oils, lubricating oils, and PAG (polyalkylene glycol) oils used in mobile A/C, and R134a systems, compared with refrigerant R134a, refrigerant R152a is highly compatible with R134a systems, and offers high cooling efficiency, higher latent heat and lower vapor density, this make it a direct drop-in replacement for R134a in new refrigeration system, commercial air conditioning, thermostatic valves, expansion valves, and compressors.

Performance
Refrigerant R152a is known for its high performance, due to its thermodynamic properties, refrigerant R152A provides approximately 20% higher cooling efficiency and 20% higher energy efficiency. Besides this, refrigerant R152a ensures 10-20% COP (coefficient of performance), while it offers 57% higher latent heat of vaporization. Compared with R134a, refrigerant R152a has slightly 10% lower operating pressures, but due to the molecular weight, R152a require 30% lower refrigerant charge; these factors make it excellent for mobile air conditioning (MAC) systems, commercial cooling, and refrigeration applications.
Safety Requirements
R152a is classified as an A2 refrigerant, meaning it has low toxicity but is flammable and requires proper safety precautions during handling and system design.
Refrigerant R152A is fully compliant with the European Regulation 517/2014. Because R152a is flammable, equipment design must comply with local safety regulations regarding refrigerant charge limits, ventilation, and ignition source protection.
Likewise, a leak detector in refrigeration units is required to ensure sufficient ventilation. Other safety solutions, such as an automatic ventilation system or non-explosion-proof electrical equipment, are also recommended.
Environmentally friendly
R152A refrigerant(Difluoroethane is not ozone-depleting) is a completely ozone-friendly refrigerant with an ozone depletion potential (ODP) of zero, making it an environmentally-friendly alternative to R134a, which does not damage the ozone layer, and contributes to the reduction of greenhouse gas emissions by 90%. Compared to R134A, with a high-GWP HFC value of 1,430, R152A refrigerant has a very low global warming potential (GWP) of 138 (IPCC AR5), significantly lower than R134A’s GWP of 1,430; thus, refrigerant R152A has a lower environmental impact and reduces CO2 emissions.

Lower System Charge
R152A refrigerant offers lower charge systems, thanks to the lower molecular weight and density saturated liquid, which allows the system to operate effectively with 40% less refrigerant charge volume than refrigerant R134a, while it delivers higher cooling efficiency and 20% higher energy efficiency.
R152a vs R134a Comparison Table
| Property | R152a | R134a |
|---|---|---|
| GWP | 124-138 | 1430 |
| ODP | 0 | 0 |
| Safety Class | A2 | A1 |
| Flammability | Yes | No |
| Energy Efficiency | Higher | Standard |
| Refrigerant Charge | Lower | Higher |
Is R152a Refrigerant Right for Your System?
Choose R125a Refrigerant if:
- You need a low-GWP refrigerant
- Energy efficiency is a priority
- Your system can safely handle A2 refrigerants
- You are replacing R134a
Avoid R125a Refrigerant if:
- You require a non-flammable refrigerant
- Local regulations restrict A2 refrigerants
- Existing equipment is not designed for flammable refrigerants
Conclusion
Refrigerant R152A cooling performance and superior energy-efficiency make it a top choice for the eco-conscious refrigeration and air conditioning industry. Despite being slightly flammable, refrigerant R152A is vital for systems designed with proper safety standards and environmental measures.
FAQ
Is R152a a replacement for R134a?
Yes. R152a is often considered a lower-GWP alternative to R134a and can provide higher energy efficiency in suitable systems.
Can R152a replace R134a directly?
While their using pressure conditions are similar, R152a cannot be a simple replacement because of its A2 flammability and higher discharge temperature. System modification is required.
What oil is compatible with R152a?
R152a is generally compatible with POE lubricants.
Is R152a environmentally friendly?
Compared with R134a, R152a has a much lower GWP and zero ozone depletion potential, making it a more environmentally responsible option.
Why Is R152a Considered a Replacement for R134a?
Because R152a refrigerant and R134a refrigerant both have these properties:
- Similar operating pressure
- Higher energy efficiency
- Lower GWP
- Reduced refrigerant charge requirement


