If you’re looking for a more eco-friendly refrigerant, R600 is worth your attention. It’s widely used for its environmental performance and strong cooling performance. Here’s what you need to know about what it is, where it’s used, and how to use it safely.
What is R600 Refrigerant?
R600 (C₄H₁₀), also known as n-butane, is a hydrocarbon refrigerant. It is a hydrocarbon with colorless, odorless, and flammable. At room temperature and pressure, R600 exists in gaseous form and can be liquefied by pressurization or cooling. This makes it easy for you to store and transport.
R600 refrigerant is considered an ideal alternative to traditional fluorine refrigerants because it does not harm the ozone layer (ODP = 0) and has an extremely low global warming potential (GWP ≈ 4). In addition, R600 is widely used in foaming, as a solvent, and as a fuel. It also plays a key role in supporting greener industrial processes.

The Properties of R600 Refrigerant
You can see the physical and chemical properties of R600 refrigerant:
| Refrigerant | R600 |
| Name | n-butane |
| Formula | C4H10 |
| Flammability | Highly flammable |
| Global Warming Potential (GWP) | 3.3 |
| Ozone Depletion Potential | 0 |
| Operating Pressure at 25°C | 2.2 MPa |
| Upper Explosive Limit (Vol.) Gas In Air) | 8.5% |
| Lower Explosive Limit (Vol.) Gas In Air) | 1.9% |
| Normal boiling point | -0.5℃ |
| Critical temperature | 152℃ |
| Critical pressure | 3.8MPa |
| Latent Heat (Vaporization at 0℃) | 385kJ/kg |
| Safety Classification | A3 |
R600 Refrigerant Pressure Chart
If you want to choose R600 refrigerant for your project. You should see the simplified R600 pressure chart showing pressure at different temperatures:
| Temperature (°C) | Pressure (bar) |
| -20 | 0.4 |
| -10 | 0.7 |
| 0 | 1.1 |
| 10 | 1.6 |
| 20 | 2.1 |
| 25 | 2.4 |
| 30 | 2.8 |
| 40 | 3.7 |
| 50 | 4.8 |
Advantages of R600 Refrigerant
Efficient and Energy-saving
R600 refrigerant has excellent physical properties, such as a low boiling point and high latent heat of evaporation. It evaporates quickly and absorbs heat efficiently, which improves system performance.
If you use R600 refrigerant in your refrigeration equipment, it can deliver a high coefficient of performance(COP), helping you reduce using costs.
Environmental Compliance
The biggest advantage of R600 refrigerant is its environmental performance. As a natural hydrocarbon, R600 refrigerant has no harmful effect on the ozone layer. Its global warming potential is extremely low, only about four times that of carbon dioxide, far lower than traditional fluorinated refrigerants.
R600, as a naturally occurring hydrocarbon, does not form persistent pollution in the atmosphere. It complies with major environmental regulations such as the Kigali Amendment, EU F-Gas rules, and the US SNAP program.
Excellent Thermal Insulation Performance
In the foaming field, R600 can produce high-quality foam with uniform pores and low thermal conductivity. These foam materials have excellent thermal insulation performance and are widely used in building walls, roofs, floor heating, cold storage insulation, and other fields. The foam plate produced with R600 foaming agent not only has excellent thermal insulation, but also can improve overall energy efficiency in your system.
| Temperature (℃) | Absolute pressure (bar) | Liquid density (kg/l) | Gas density (kg/l) | Liquid enthalpy (kJ/kg) | Gas enthalpy (kJ/kg) |
| -50 | 0.094668 | 0.65171 | 0.00029877 | 89.424 | 515.56 |
| -45 | 0.127 | 0.64681 | 0.00039275 | 100.07 | 522.35 |
| -40 | 0.16791 | 0.64188 | 0.00050921 | 110.8 | 529.19 |
| -35 | 0.21902 | 0.63691 | 0.00065184 | 121.62 | 536.08 |
| -30 | 0.2821 | 0.63189 | 0.00082463 | 132.52 | 543.01 |
| -25 | 0.35909 | 0.62684 | 0.0010319 | 143.51 | 549.98 |
| -20 | 0.45213 | 0.62173 | 0.0012782 | 154.6 | 556.98 |
| -15 | 0.56346 | 0.61657 | 0.0015684 | 165.79 | 564.02 |
| -10 | 0.69552 | 0.61135 | 0.0019078 | 177.08 | 571.08 |
| -5 | 0.85089 | 0.60608 | 0.002302 | 188.48 | 578.17 |
| 0 | 1.0323 | 0.60073 | 0.0027567 | 200 | 585.27 |
| 5 | 1.2425 | 0.59532 | 0.0032783 | 211.64 | 592.39 |
| 10 | 1.4845 | 0.58983 | 0.0038734 | 223.4 | 599.53 |
| 15 | 1.7615 | 0.58425 | 0.004549 | 235.28 | 606.66 |
| 20 | 2.0765 | 0.57859 | 0.0053126 | 247.3 | 613.8 |
| 25 | 2.4329 | 0.57283 | 0.0061722 | 259.46 | 620.94 |
| 30 | 2.8341 | 0.56698 | 0.0071366 | 271.76 | 628.06 |
| 35 | 3.2836 | 0.56101 | 0.008215 | 284.21 | 635.17 |
| 40 | 3.7848 | 0.55492 | 0.0094176 | 296.82 | 642.25 |
| 45 | 4.3416 | 0.5487 | 0.010755 | 309.58 | 649.31 |
| 50 | 4.9575 | 0.54234 | 0.012241 | 322.51 | 656.32 |
Cost-Effective and Widely Available
R600 is produced as a byproduct of petroleum refining and natural gas processing. It is widely available and cost-effective. Compared to synthetic refrigerants, R600 has a lower price. It helps reduce your refrigeration costs. In addition, the easy availability of R600 ensures its supply stability, giving you a stable and reliable supply.
Good Compatibility
R600 has good compatibility with traditional lubricants such as mineral oil and alkylbenzene oil. It can still maintain fluidity at low temperatures. For example, when you use R600 with mineral oil in commercial systems, it can help reduce compressor wear and extend service life.
R600 has no corrosive effect on common metals such as copper and aluminum. Using R600 refrigerant, it also helps reduce corrosion in system components. It significantly extends the life of the heat exchanger.
Disadvantages of R600 Refrigerant
Flammable
The biggest disadvantage of R600 refrigerant is its flammability. As an A3 safety level refrigerant, R600 has a wide range of explosive limits in air (1.86% -8.41% volume concentration). It can easily ignite when exposed to heat, sparks, or open flames.
Therefore, in the process of using R600 refrigerant, it is necessary to follow the proper safety procedures. You need to make sure the system is properly designed for explosion safety. Make sure your work area is well ventilated, and avoid contact with ignition sources.

Strict Control of Filling Volume
The charging amount of R600 refrigerant in the refrigeration system needs to be strictly controlled. Excessive or insufficient filling can cause you trouble. If the charge is:
- Too low: Your system may not cool properly. Its suction pressure will drop. It can cause abnormal machine sound and reduce compressor life.
- Too high: The system can overheat and become unsafe.
Therefore, you need to pay attention to using accurate charging equipment when filling R600 refrigerant to ensure an accurate filling amount.
Applications of R600 Refrigerant
Refrigeration Field
R600 refrigerant is widely used in the refrigeration field, best suited for medium and high temperature refrigeration applications. You’ll typically see it used in systems like air conditioners, heat pumps, and commercial display refrigerators.
In addition, R600 is often used as a component of mixed refrigerants to improve the performance and stability of refrigeration systems.

Foam Field
In the foaming field, R600 is widely used in the production of plastic foam such as polystyrene (PS), extruded polystyrene (XPS), and polyolefin (PO). The foam plate produced with R600 foaming agent has excellent thermal insulation performance and dimensional stability, and is widely used in building walls, roofs, floor heating, cold storage insulation, and other fields.
Solvents and Fuels
R600 refrigerant can also be used as a solvent and fuel. In industries such as chemical, pharmaceutical, and food:
- R600 is used as a solvent or extractant for extracting and purifying organic compounds.
- R600 can also be used as a lighter gas, portable gas tank fuel, and propellant for some aerosol products, meeting the needs of daily life and industrial production.
Precautions for Using R600 Refrigerant
Safe Operation
You need to handle R600 with care due to its flammability. Before using R600 refrigerant, you need to ensure that:
- The operating area must be well ventilated to avoid contact with fire sources.
- You should only allow trained technicians to handle it
- When adding refrigerant, charging hoses and fittings should be used to avoid the risk of leakage and explosion.
- The equipment should be equipped with explosion-proof electrical components and combustible gas alarms to ensure safe operation.
Charging Volume Control
The charging amount of R600 refrigerant must be strictly controlled. Excessive or insufficient charging can affect the cooling effect and equipment energy efficiency. Therefore, in practical operation, high-precision refrigerant filling equipment should be used to fill according to the specified filling amount on the equipment nameplate. At the same time, regularly check the system pressure to ensure the accuracy of the filling amount.
Equipment Maintenance and Repair
Regular maintenance and overhaul are important to ensure the normal operation and extend the service life of equipment using R600 refrigerant:
- During maintenance, the sealing of the system should be checked to avoid the risk of leakage and explosion.
- Regularly replace the dry filter and lubricating oil to ensure the cleanliness and lubrication of the system.
- When performing maintenance, always work in a well-ventilated area.
To Wrap Up
R600 gives you an efficient and eco-friendly option for modern refrigeration. But because it’s flammable, you need to handle it carefully. If you have any questions about R600 refrigerant information, reach out to our team for expert support.
FAQ
Is R600 refrigerant safe to use?
Yes. Because it has an A3 safety classification (highly flammable), you need proper ventilation and trained technicians.
What is the difference between R600 and R600a?
R600 refrigerant is n-butane, while R600a is isobutane. R600a refrigerant is more commonly used in household refrigerators.
Can you retrofit R134a systems with R600?
No. You should not directly replace R134a with R600 because of safety and system design differences.
Why is R600 considered environmentally friendly?
It has zero ozone depletion potential and a very low global warming potential of about 3.3.
Where is R600 mainly used?
You’ll find it in commercial refrigeration, foaming applications, and some industrial processes.
You may also find this related blog post useful:
What refrigerant is used in refrigerators?
Which gas is used in air conditioners?
What is refrigerant, the-ultimate-guide?
What is the 404A Refrigerant Operating Pressure in a Walk-In Freezer?



